Performance very slown in pages C#

I have an application running in production developed in ASP.NET 4.6, the application to be published or at any time it takes approximately 1 min to load each page, I have already tested it on other Production servers and with less resources and the application works perfectly.
I performed a query on an API to check the return time, and to bring 1 record took 700 milliseconds ...
Could anyone help?
In some cases I need to reset IIS several times until it returns to normal.