The requested content appears to be script and will not be served by the static file handler.

Hello, I have an Asp.net Framework 2.0 website running on IIS 7.5.  Under this same site, I have deployed another application which is running under framework 4.0 application pool (Classic Mode).  When I run the 4.0 application, I get the following error, "

The requested content appears to be script and will not be served by the static file handler."

 I think, I might be able to fix the issue by running aspnet_regiis -i against 4.0 framwork but I am afraid if it would screw up the site which is running under a Framework 2.0 application pool. 

 Is there anyone run both frameworks on under the same site?

 thanks

Jake