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Best practice for Servers running 50-100 sites, and 300+ app pools?

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Hi,

Are there any best practices for web servers running 300+ app pools in regards to memory, etc?  Our web servers will have about 100 sites on each, each running a very large .net application with 3 application pools.  Memory is of course a cause for concern, and our web servers have 18+gb of memory each to combat the situation.  Is there any best practice for web servers of this size? if so, I have not been able to find any but we can't be the only place that does it like this.

Thanks.


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